The ongoing debate on the ethics of using artificial intelligence (AI) in military contexts has been negatively impacted by the predominant focus on the use of lethal autonomous weapon systems (LAWS) in war. However, AI technologies have a considerably broader scope and present opportunities for decision support optimization across the entire spectrum of the military decision-making process (MDMP). These opportunities cannot be ignored. Instead of mainly focusing on the risks of the use of AI in target engagement, the debate about (...) responsible AI should (i) concern each step in the MDMP, and (ii) take ethical considerations and enhanced performance in military operations into account. A characterization of the debate on responsible AI in the military, considering both machine and human weaknesses and strengths, is provided in this paper. We present inroads into the improvement of the MDMP, and thus military operations, through the use of AI for decision support, taking each quadrant of this characterization into account. (shrink)

The natural input memory (NIM) model is a new model for recognition memory that operates on natural visual input. A biologically informed perceptual preprocessing method takes local samples (eye fixations) from a natural image and translates these into a feature‐vector representation. During recognition, the model compares incoming preprocessed natural input to stored representations. By complementing the recognition memory process with a perceptual front end, the NIM model is able to make predictions about memorability based directly on individual natural stimuli. We (...) demonstrate that the NIM model is able to simulate experimentally obtained similarity ratings and recognition memory for individual stimuli (i.e., face images). (shrink)

The long-awaited revision of the industry standard on phylogenetics Since the publication of the first edition of this landmark volume more than twenty-five years ago, phylogenetic systematics has taken its place as the dominant paradigm of systematic biology. It has profoundly influenced the way scientists study evolution, and has seen many theoretical and technical advances as the field has continued to grow. It goes almost without saying that the next twenty-five years of phylogenetic research will prove as fascinating as the (...) first, with many exciting developments yet to come. This new edition of Phylogenetics captures the very essence of this rapidly evolving discipline. Written for the practicing systematist and phylogeneticist, it addresses both the philosophical and technical issues of the field, as well as surveys general practices in taxonomy. Major sections of the book deal with the nature of species and higher taxa, homology and characters, trees and tree graphs, and biogeography—the purpose being to develop biologically relevant species, character, tree, and biogeographic concepts that can be applied fruitfully to phylogenetics. The book then turns its focus to phylogenetic trees, including an in-depth guide to tree-building algorithms. Additional coverage includes: Parsimony and parsimony analysis Parametric phylogenetics including maximum likelihood and Bayesian approaches Phylogenetic classification Critiques of evolutionary taxonomy, phenetics, and transformed cladistics Specimen selection, field collecting, and curating Systematic publication and the rules of nomenclature Providing a thorough synthesis of the field, this important update to Phylogenetics is essential for students and researchers in the areas of evolutionary biology, molecular evolution, genetics and evolutionary genetics, paleontology, physical anthropology, and zoology. (shrink)

I venture to call the attention of classical scholars to two legends about Roman Emperors gleaned amid the arid waste of theological nonsense which passed for literature among the Copts, in the hope that they may have better luck than I have had in tracing them to some classical source. The first is taken from MS. Par. Copte 131, fol. 40, a single leaf of what seems to be a geographical and historical encyclopaedia.1 The writer who is treating in a (...) very discursive way of Ethiopia, states that Nero or Domitian—a strange pair to run in double harness—caused an island in the Red Sea to be watered with oil. The description of that island is mixed up with a mention of the original divisions of the Indians—a term which as usual in early days embraces both Indians and Ethiopians,—and their subsequent changes; and as that too may be of interest to students of ancient geography, I will translate the passage in full. (shrink)

I DO not think that it is at all generally known that among the Egyptian antiquities given by Grant Bey to the Museum at Aberdeen there are a considerable number of papyrus fragments, Greek, Coptic,1 Hieratic, Demotic, and even Latin and Arabic, which except for an inspection by Prof. Sayce and a passing visit of Dr. Grenfell have up till now been left unexamined. That indeed is my only reason for trespassing in a branch of Palaeography with which I am (...) quite unfamiliar; and it is in the hope of inciting some experienced papyrologist to turn his attention to them that I publish the following fragments. In the case of the Greek fragments lack of time combined with a mistrust of my powers of deciphering the more illegible non-literary hands forbade me do more than select the most promising literary fragments. Among these Homer naturally predominates; but the gem of the collection is a lyric fragment, which may fairly certainly be ascribed to Alcaeus, though Dr. Grenfell who first noticed it attributed it to Sappho. A fragment of Demosthenes, a fragment of Dioscorides, and a vellum fragment of a Latin Bible, were the only others which I succeeded in identifying; but these, with the few tragic, comic, and medical fragments which I also reproduce, are, I think, first-fruits sufficient to show that the crop would not be barren, if it found a competent gleaner. (shrink)

With a few exceptions, Thomists have by and large failed to engage with the historical and hermeneutical turns in philosophy and theology. This article offers an account of what the beginnings of a Thomistic engagement with recent hermeneutical philosophy might look like. In order to develop such an account, the author turns to arguably the most important contemporary hermeneutical philosopher, namely Hans-Georg Gadamer, as a dialogue partner. Despite claims to the contrary, this article argues that Gadamer does not successfully deal (...) with the specter of relativism. It goes on to show how that the thought of Thomas Aquinas can ably deal with this specter. There are two central elements in the argument put forward. Firstly, the author argues that the human being exists in between God as First Efficient Cause of all that exists and God as Final Cause of all that exists. This existence between God as First Efficient Cause of all that exists and God as Final Cause of all that exists furnishes the connatural context in which human knowing and willing unfolds. Secondly, he considers the dynamics of “interinvolvement” between intellect and will. The upshot of these arguments is a construal of reason that is at once capable of universal truth and hermeneutical in nature. Indeed, the universal range of reason and its hermeneutical dimension are in no way opposed to each other: they are rather dual aspects of one and the same reality. (shrink)

This is an authentic record of an unauthentic paper.

The eukaryotic helicase is an 11-subunit machine containing an Mcm2-7 motor ring that encircles DNA, Cdc45 and the GINS tetramer, referred to as CMG. CMG is “built” on DNA at origins in two steps. First, two Mcm2-7 rings are assembled around duplex DNA at origins in G1 phase, forming the Mcm2-7 “double hexamer.” In a second step, in S phase Cdc45 and GINS are assembled onto each Mcm2-7 ring, hence producing two CMGs that ultimately form two replication forks that travel (...) in opposite directions. Here, we review recent findings about CMG structure and function. The CMG unwinds the parental duplex and is also the organizing center of the replisome: it binds DNA polymerases and other factors. EM studies reveal a 20-subunit core replisome with the leading Pol ϵ and lagging Pol α-primase on opposite faces of CMG, forming a fundamentally asymmetric architecture. Structural studies of CMG at a replication fork reveal unexpected details of how CMG engages the DNA fork. The structures of CMG and the Mcm2-7 double hexamer on DNA suggest a completely unanticipated process for formation of bidirectional replication forks at origins. Here, we review the structure and function of CMG, the 11 subunit helicase for eukaryotic DNA replication. Two CMGs are assembled at origins starting from two Mcm2-7 hexamers oriented N-to-N. The orientation of CMG at a forked DNA implies that the two CMGs at an origin pass one another. (shrink)

A series of summary descriptions of the theories of the Pre-Socratics, Sophists, Socrates, Plato, Aristotle, Stoics, Epicureans, Sceptics, and Gnostics, the book suffers from controversial points made in an off-hand fashion. The two following interpretations are especially perplexing, if not erroneous: that Plato's philosophy is "materialistic in outlook" since by ideas he means "the material perfects of the material imperfects"; and that "the Atomistic philosophy is teleological" since it depicts the atoms as "intelligent agents," "striving for an ultimate purpose."—E. O. (...) T. (shrink)

DEATH is one of the central themes of existentialist writing. This is to be expected since the focal point of all its reflection is human existence. Existentialism explores the innermost depths of experienced selfhood. Inevitably, the authentic self must face the problem of man’s origin and destiny or, in Heideggerian terms, the beginning and ending of his Being-in-the-world. Death is a profoundly human problem, inseparably bound up with the psychological and ontological structure of the human mode of being or Dasein.